Exposure to psychotropic medications and mortality in schizophrenia: a 5-year national cohort study.

ABSTRACT:

Background

Relatively few studies have explored the differential contributions of the accumulative dosage of psychotropic medications on mortality in patients with schizophrenia.

Methods

We aimed to explore the effects of the exposure dosage of psychotropic medications on mortality during a follow-up period of 5 years with a national cohort of individuals with schizophrenia in 2010. Causes of death were linked through Taiwan's National Mortality Registry. The mean defined daily dose of antipsychotics, antidepressants, mood stabilizers, and sedative-hypnotics, were calculated and survival analyses were conducted.

Results

A total of 102 964 individuals (54 151 men, 52.59%) with schizophrenia were included. Compared to patients with no exposure to antipsychotics, those w

SUBMITTER: Lin JY 

PROVIDER: S-EPMC10482725 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature