Intra-tidal PaO₂ oscillations associated with mechanical ventilation: a pilot study to identify discrete morphologies in a porcine model.

ABSTRACT:

Background

Within-breath oscillations in arterial oxygen tension (PaO₂) can be detected using fast responding intra-arterial oxygen sensors in animal models. These PaO₂ signals, which rise in inspiration and fall in expiration, may represent cyclical recruitment/derecruitment and, therefore, a potential clinical monitor to allow titration of ventilator settings in lung injury. However, in hypovolaemia models, these oscillations have the potential to become inverted, such that they decline, rather than rise, in inspiration. This inversion suggests multiple aetiologies may underlie these oscillations. A correct interpretation of the various PaO₂ oscillation morphologies is essential to translate this signal into a monitoring tool for clinical practice

SUBMITTER: Cronin JN 

PROVIDER: S-EPMC10482813 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature