Novel cationic cryptides in Penaeus vannamei demonstrate antimicrobial and anti-cancer activities.

ABSTRACT: Cryptides are a subfamily of bioactive peptides that exist in all living organisms. They are latently encrypted in their parent sequences and exhibit a wide range of biological activities when decrypted via in vivo or in vitro proteases. Cationic cryptides tend to be drawn to the negatively charged membranes of microbial and cancer cells, causing cell death through various mechanisms. This makes them promising candidates for alternative antimicrobial and anti-cancer therapies, as their mechanism of action is independent of gene mutations. In the current study, we employed an in silico approach to identify novel cationic cryptides with potential antimicrobial and anti-cancer activities in atypical and systematic strategy by reanalysis of a publicly available RNA-seq dataset of Pacific white

SUBMITTER: Abd El-Aal AAA 

PROVIDER: S-EPMC10482825 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature