Predictors of rapidly progressive interstitial lung disease and prognosis in Chinese patients with anti-melanoma differentiation-associated gene 5-positive dermatomyositis.

ABSTRACT:

Background

Rapidly progressive interstitial lung disease (RP-ILD) is the most serious complication of anti-melanoma differentiation-associated gene 5-positive dermatomyositis (anti-MDA5⁺ DM). This study was performed to assess the prognostic factors of patients with anti-MDA5⁺ DM and the clinical characteristics and predictors of anti-MDA5⁺ DM in combination with RP-ILD.

Methods

In total, 73 MDA5⁺ DM patients were enrolled in this study from March 2017 to December 2021. They were divided into survival and non-survival subgroups and non-RP-ILD and RP-ILD subgroups.

Results

The lactate dehydrogenase (LDH) concentration and prognostic nutritional index (PNI) were independent prognostic factors in patients with anti-MDA5^+</

SUBMITTER: Li M 

PROVIDER: S-EPMC10483132 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature