Antidepressant Use and Mortality Among Patients With Hepatocellular Carcinoma.

ABSTRACT:

Importance

Liver cancer, primarily hepatocellular carcinoma (HCC), is the third leading cause of cancer deaths worldwide. Although some studies have proposed that antidepressants may have apoptotic effects on cancer, no study has examined the association between antidepressant use and HCC prognosis.

Objective

To investigate the association between antidepressant use and mortality risk in patients with HCC.

Design, setting, and participants

This population-based cohort study analyzed Taiwan's National Health Insurance Research Database, which covers 99% of Taiwan's population and includes comprehensive medical information. Patients with a new diagnosis of HCC between 1999 and 2017 were identified. Analysis took place in June 2023.

Main outcomes and measures

All

SUBMITTER: Huang KL 

PROVIDER: S-EPMC10483320 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature