Quantitative Susceptibility Mapping MRI in Deep-Brain Nuclei in First-Episode Psychosis.

ABSTRACT:

Background

Psychosis is related to neurochemical changes in deep-brain nuclei, particularly suggesting dopamine dysfunctions. We used an magnetic resonance imaging-based technique called quantitative susceptibility mapping (QSM) to study these regions in psychosis. QSM quantifies magnetic susceptibility in the brain, which is associated with iron concentrations. Since iron is a cofactor in dopamine pathways and co-localizes with inhibitory neurons, differences in QSM could reflect changes in these processes.

Methods

We scanned 83 patients with first-episode psychosis and 64 healthy subjects. We reassessed 22 patients and 21 control subjects after 3 months. Mean susceptibility was measured in 6 deep-brain nuclei. Using linear mixed models, we analyzed the effect of case-contr

SUBMITTER: Garcia Saborit M 

PROVIDER: S-EPMC10483330 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature