Circulating proteome for pulmonary nodule malignancy.

ABSTRACT:

Background

Although lung cancer screening with low-dose computed tomography is rolling out in many areas of the world, differentiating indeterminate pulmonary nodules remains a major challenge. We conducted one of the first systematic investigations of circulating protein markers to differentiate malignant from benign screen-detected pulmonary nodules.

Methods

Based on 4 international low-dose computed tomography screening studies, we assayed 1078 protein markers using prediagnostic blood samples from 1253 participants based on a nested case-control design. Protein markers were measured using proximity extension assays, and data were analyzed using multivariable logistic regression, random forest, and penalized regressions. Protein burden scores (PBSs) for overall nodule mal

SUBMITTER: Khodayari Moez E 

PROVIDER: S-EPMC10483334 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature