Donepezil treatment is associated with improved outcomes in critically ill dementia patients via a reduction in delirium.

ABSTRACT:

Introduction

During hospital admissions, patients with dementia are at risk for developing delirium, an acute state of brain failure associated with significant morbidity. There are currently no pharmacologic tools to treat or prevent delirium. Decreased cholinergic signaling plays a role in the pathophysiology of both disorders. Whether enhanced pre-hospital cholinergic signaling in patients with dementia improves outcomes during critical illness remains unknown.

Methods

We utilized the Medical Information Mart for Intensive Care III (MIMIC-III) database to determine whether pre-hospital donepezil use was associated with improved outcomes during critical illness in dementia patients.

Results

We identified 2734 subjects with dementia admitted to the intensive care uni

SUBMITTER: Lieberman OJ 

PROVIDER: S-EPMC10483393 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature