Pangenomic analyses of antibiotic-resistant <i>Campylobacter jejuni</i> reveal unique lineage distributions and epidemiological associations.

ABSTRACT: Application of whole-genome sequencing (WGS) to characterize foodborne pathogens has advanced our understanding of circulating genotypes and evolutionary relationships. Herein, we used WGS to investigate the genomic epidemiology of Campylobacter jejuni, a leading cause of foodborne disease. Among the 214 strains recovered from patients with gastroenteritis in Michigan, USA, 85 multilocus sequence types (STs) were represented and 135 (63.1 %) were phenotypically resistant to at least one antibiotic. Horizontally acquired antibiotic resistance genes were detected in 128 (59.8 %) strains and the genotypic resistance profiles were mostly consistent with the phenotypes. Core-gene phylogenetic reconstruction identified three sequence clusters that varied in frequency, while a neighbour-ne

SUBMITTER: Rodrigues JA 

PROVIDER: S-EPMC10483415 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature