Mapping the phylogeny and lineage history of geographically distinct BCG vaccine strains.

ABSTRACT: The bacillus Calmette-Guérin (BCG) vaccine has been in use for prevention of tuberculosis for over a century. It remains the only widely available tuberculosis vaccine and its protective efficacy has varied across geographical regions. Since it was developed, the BCG vaccine strain has been shared across different laboratories around the world, where use of differing culture methods has resulted in genetically distinct strains over time. Whilst differing BCG vaccine efficacy around the world is well documented, and the reasons for this may be multifactorial, it has been hypothesized that genetic differences in BCG vaccine strains contribute to this variation. Isolates from an historic archive of lyophilized BCG strains were regrown, DNA was extracted and then whole-genome sequenced using O

SUBMITTER: Elton L 

PROVIDER: S-EPMC10483423 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature