Modeling and Insights into the Structural Characteristics of Chemical Mitochondrial Toxicity.

ABSTRACT: Mitochondria are the energy metabolism center of cells and are involved in a number of other processes, such as cell differentiation and apoptosis, signal transduction, and regulation of cell cycle and cell proliferation. It is of great significance to evaluate the mitochondrial toxicity of drugs and other chemicals. In the present study, we aimed to propose easily available artificial intelligence (AI) models for the prediction of chemical mitochondrial toxicity and investigate the structural characteristics with the analysis of molecular properties and structural alerts. The consensus model achieved good predictive results with high total accuracy at 87.21% for validation sets. The models can be accessed freely via https://ochem.eu/article/158582. Besides, several commonly used chemical

SUBMITTER: Zhang R 

PROVIDER: S-EPMC10483523 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature