Polymerization force-regulated actin filament-Arp2/3 complex interaction dominates self-adaptive cell migrations.

ABSTRACT: Cells migrate by adapting their leading-edge behaviors to heterogeneous extracellular microenvironments (ECMs) during cancer invasions and immune responses. Yet it remains poorly understood how such complicated dynamic behaviors emerge from millisecond-scale assembling activities of protein molecules, which are hard to probe experimentally. To address this gap, we establish a spatiotemporal "resistance-adaptive propulsion" theory based on the interactions between Arp2/3 complexes and polymerizing actin filaments and a multiscale dynamic modeling system spanning from molecular proteins to the cell. We quantitatively find that cells can accurately self-adapt propulsive forces to overcome heterogeneous ECMs via a resistance-triggered positive feedback mechanism, dominated by polymerization-in

SUBMITTER: Chen X 

PROVIDER: S-EPMC10483647 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature