Structural Framework for Analysis of CD4+ T-Cell Epitope Dominance in Viral Fusion Proteins.

ABSTRACT: Antigen conformation shapes CD4+ T-cell specificity through mechanisms of antigen processing, and the consequences for immunity may rival those from conformational effects on antibody specificity. CD4+ T cells initiate and control immunity to pathogens and cancer and are at least partly responsible for immunopathology associated with infection, autoimmunity, and allergy. The primary trigger for CD4+ T-cell maturation is the presentation of an epitope peptide in the MHC class II antigen-presenting protein (MHCII), most commonly on an activated dendritic cell, and then the T-cell responses are recalled by subsequent presentations of the epitope peptide by the same or other antigen-presenting cells. Peptide presentation depends on the proteolytic fragmentation of the antigen in an endosomal/l

SUBMITTER: Landry SJ 

PROVIDER: S-EPMC10483696 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature