The cause and effect of gut microbiota in development of inflammatory disorders of the breast.

ABSTRACT:

Background

Inflammatory disorders of the breast (IDB) damages the interests of women and children and hinders the progress of global health seriously. Several studies had offered clues between gut microbiota (GM) and inflammatory disorders of the breast (IDB). The gut-mammary gland axis also implied a possible contribution of the GM to IDB. However, the causality between them is still elusive.

Methods

The data of two-sample Mendelian randomization (MR) study related to the composition of GM (n = 18,340) and IDB (n = 177,446) were accessed from openly available genome-wide association studies (GWAS) database. As the major analytical method, inverse variance weighted (IVW) was introduced and several sensitive analytical methods were conducted to verify results.

Results

SUBMITTER: Gu Y 

PROVIDER: S-EPMC10483784 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature