Cell-therapy for Parkinson's disease: a systematic review and meta-analysis.

ABSTRACT:

Background

Cell-based strategies focusing on replacement or protection of dopaminergic neurons have been considered as a potential approach to treat Parkinson's disease (PD) for decades. However, despite promising preclinical results, clinical trials on cell-therapy for PD reported mixed outcomes and a thorough synthesis of these findings is lacking. We performed a systematic review and meta-analysis to evaluate cell-therapy for PD patients.

Methods

We systematically identified all clinical trials investigating cell- or tissue-based therapies for PD published before July 2023. Out of those, studies reporting transplantation of homogenous cells (containing one cell type) were included in meta-analysis. The mean difference or standardized mean difference in quantitative neurol

SUBMITTER: Wang F 

PROVIDER: S-EPMC10483810 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature