Anti-TNF Therapy Regulates Phagosome Pathway by Inhibiting NCF4 Expression to Treat Ankylosing Spondylitis.

ABSTRACT:

Objectives

Ankylosing spondylitis (AS) is challenging to diagnose in its early stages, and treatment options are limited.

Methods

GEO2R analysis and weighted gene co-expression network analysis (WGCNA) were used to identify DEGs and key modules. Kyoto Encyclopedia of Genes and Genomes analysis and Protein-protein interactions were used to identify core genes. Receiver operating characteristic curve, chi-square and t-test were used to analyze the correlation between gene expression and clinicopathological characteristics. Gene expression was detected using Real-time polymerase chain reaction and western blotting.

Results

GEO2R analysis and WGCNA identified 1100 DEGs and brown module. The KEGG analysis revealed that 444 core genes were closely associated with specific p

SUBMITTER: Liu S 

PROVIDER: S-EPMC10483821 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature