Shift work and risk of incident gastroesophageal reflux disease: the association and mediation.

ABSTRACT:

Introduction

Shift work has become an increasingly common work mode globally. This study aimed to investigate the association between shift work and the risk of incident gastroesophageal reflux disease (GORD), an upward gastrointestinal disorder disease worldwide, and to explore the mediating factors.

Method

A total of 262,722 participants from the UK Biobank free of GORD and related gastrointestinal diseases were included to investigate the association and potential mediators between shift work and incident GORD. Multivariate-adjusted Cox models were used to evaluate the association between shift work status and GORD incidence.

Results

Compared to non-shift workers, shift workers had a 1.10-fold greater risk of incident GORD [95% confidence intervals (CIs): 1.03, 1.1

SUBMITTER: Li Q 

PROVIDER: S-EPMC10483823 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature