The association between newborn cord blood steroids and ambient prenatal exposure to air pollution: findings from the ENVIRONAGE birth cohort.

ABSTRACT: Knowledge of whether prenatal exposure to ambient air pollution disrupts steroidogenesis is currently lacking. We investigated the association between prenatal ambient air pollution and highly accurate measurements of cord blood steroid hormones from the androgenic pathway.This study included 397 newborns born between the years 2010 and 2015 from the ENVIRONAGE cohort in Belgium of whom six cord blood steroid levels were measured: 17α-hydroxypregnenolone, 17α-hydroxyprogesterone, dehydroepiandrosterone, pregnenolone, androstenedione, and testosterone. Maternal ambient exposure to PM_2.5 (particles with aerodynamic diameter ≤ 2.5 μm), NO_2, and black carbon (BC) were estimated daily during the entire pregnancy using a high-resolution spatiotemporal model. The association

SUBMITTER: Plusquin M 

PROVIDER: S-EPMC10483875 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature