Pre-training working memory/information processing capabilities and brain atrophy limit the improving effects of cognitive training.

ABSTRACT:

Background

Computerized training in persons with multiple sclerosis (PwMS) seems to enhance working memory (WM)/information processing (IP), but factors associated with the efficacy of the treatment have not been sufficiently explored. Objective: To identify clinical and radiological characteristics associated with positive WM/IP training responses.

Methods

Radiological and neuropsychological assessments were carried out on a sample of 35 PwMs who were divided into "WM/IP-impaired" and "WM/IP-preserved." All participants underwent adaptive n-back training for 10 days and were assessed post-training. Between-group differences ("WM/IP-impaired" vs. "WM/IP-preserved") in training-induced cognitive improvement were assessed and exploratory correlational/ regression-based methods

SUBMITTER: Esbri SF 

PROVIDER: S-EPMC10483983 | biostudies-literature | 2023 Jul-Sep

REPOSITORIES: biostudies-literature