Genomic epidemiology sheds light on the emergence and spread of <i>Mycobacterium bovis</i> Eu2 Clonal Complex in Portugal.

ABSTRACT: ABSTRACTAnimal tuberculosis (TB) remains a serious concern for animal and human health. Mycobacterium bovis circulates in multi-host systems, dominated by the European 2 clonal complex (Eu2) in Iberia. In this work, we use genomic epidemiology to infer the emergence, spread, and spatiotemporal patterns of Eu2 in the official epidemiological risk area of animal TB in Portugal. Phylogenetic analysis of 144 M. bovis whole-genome sequences from cattle, wild boar, and red deer, representing the 2002-2021 period, distinguished three Eu2 clades that evolved independently. The major Eu2 clade underwent phylodynamic inferences to estimate the time and location of outbreaks, host transitions, and spatial diffusion as well. The origin of this Eu2 clade was attributed to the red d

SUBMITTER: Pereira AC 

PROVIDER: S-EPMC10484045 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature