[Association of gene polymorphisms of MyD88 and TICAM1 and their interactions with community-acquired pneumonia in children].

ABSTRACT:

Objectives

To investigate the association of single nucleotide polymorphisms (SNPs) of myeloid differentiation factor 88 (MyD88) and Toll-like receptor adaptor molecule 1 (TICAM1) and their interactions with community-acquired pneumonia (CAP) in children.

Methods

Improved multiple ligase detection reaction assay was used for detecting the polymorphisms of nine tagging SNPs of the MyD88 and TICAM1 genes in 375 children with CAP who attended the Department of Pediatrics of the Second Affiliated Hospital of Yan'an University Medical School from August 2015 to September 2017 and 306 healthy children who underwent physical examination. A logistic regression analysis was used to evaluate the association between the distribution of genotypes and their in

SUBMITTER: Yang Y 

PROVIDER: S-EPMC10484080 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature