Chronic unpredictable mild stress promotes atherosclerosis via adipose tissue dysfunction in ApoE^-/- mice.

ABSTRACT:

Background

Chronic unpredictable mild stress (CUMS) has been shown to exacerbate atherosclerosis, but the underlying mechanism remains unknown. Adipose tissue is an energy storage organ and the largest endocrine organ in the human body, playing a key role in the development of cardiovascular disease. In this research, it was hypothesized that CUMS may exacerbate the development of atherosclerosis by inducing the hypertrophy and dysfunction of white adipocytes.

Methods

The CUMS-induced atherosclerosis model was developed in Western diet-fed apolipoprotein E (ApoE)^-/- mice. White adipose tissue (WAT), serum, aortic root, and the brachiocephalic trunk were collected and tested after 12 weeks of CUMS development. The mouse model of CUMS was evaluated for depression-li

SUBMITTER: Mao M 

PROVIDER: S-EPMC10484201 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature