Association of Early Beta-Blocker Exposure and Functional Outcomes in Critically Ill Patients With Moderate to Severe Traumatic Brain Injury: A Transforming Clinical Research and Knowledge in Traumatic Brain Injury Study.

ABSTRACT:

Objectives

We aimed to 1) describe patterns of beta-blocker utilization among critically ill patients following moderate-severe traumatic brain injury (TBI) and 2) examine the association of early beta-blocker exposure with functional and clinical outcomes following injury.

Design

Retrospective cohort study.

Setting

ICUs at 18 level I, U.S. trauma centers in the Transforming Clinical Research and Knowledge in TBI (TRACK-TBI) study.

Patients

Greater than or equal to 17 years enrolled in the TRACK-TBI study with moderate-severe TBI (Glasgow Coma Scale of <13) were admitted to the ICU after a blunt TBI.

Interventions

None.

Measurements

Primary exposure was a beta blocker during the first 7 days in the ICU, with a primary outcome of 6-month Glasgow Ou

SUBMITTER: Kelly-Hedrick M 

PROVIDER: S-EPMC10484371 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature