The causal relationship between multiple autoimmune diseases and nasal polyps.

ABSTRACT:

Background

Although previous sporadic studies have reported the associations between a few autoimmune diseases and nasal polyps, these studies have limitations such as conflicting results, small sample sizes, and low levels of evidence.

Methods

Several autoimmune diseases were selected as exposures while the nasal polyps were selected as outcomes. Bidirectional univariable Mendelian randomization and multivariable Mendelian randomization analyses were performed after rigorous screening of instrumental variables. Then mediation analyses were conducted to further investigate the underlying mechanisms.

Results

For the first time, we investigated the causal relationships between nine autoimmune diseases and nasal polyps in different genders and found: (1) there was a caus

SUBMITTER: Chen S 

PROVIDER: S-EPMC10484405 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature