Expression profiling identifies key genes and biological functions associated with eosinophilic esophagitis in human patients.

ABSTRACT:

Introduction

Eosinophilic Esophagitis (EoE) is a chronic allergic disease characterized by progressive inflammation of the esophageal mucosa. This chronic inflammatory disorder affects up to 50 per 100,000 individuals in the United States and Europe yet is limited in treatment options. While the transcriptome of EoE has been reported, few studies have examined the genetics among a cohort including both adult and pediatric EoE populations. To identify potentially overlooked biomarkers in EoE esophageal biopsies that may be promising targets for diagnostic and therapeutic development.

Methods

We used microarray analysis to interrogate gene expression using esophageal biopsies from EoE and Control subjects with a wide age distribution. Analysis of differential gene expression (

SUBMITTER: Morrison HA 

PROVIDER: S-EPMC10484407 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature