A pilot study of alterations of the gut microbiome in canine chronic kidney disease.

ABSTRACT:

Introduction

Gut dysbiosis has been noted in humans and animals with chronic kidney disease (CKD). However, little is known about the gut microbiome in canine patients with CKD. This study aimed to analyze and compare the gut microbiome profiles of healthy and CKD dogs, including differences in the gut microbiome between each CKD stage.

Methods

The study was conducted on 29 client-owned dogs who underwent physical examination, complete blood count (CBC), serum biochemistry, and urinalysis. The gut microbiome profile of healthy dogs (n = 10) and dogs with CKD (n = 19) was analyzed employing 16S rRNA sequencing.

Results

Significant differences were seen in the composition of the gut microbiome, with increased operational taxonomic units from the phylum

SUBMITTER: Kim KR 

PROVIDER: S-EPMC10484476 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature