Polymyxin derivatives as broad-spectrum antibiotic agents.

ABSTRACT: We designed a few polymyxin derivatives which exhibit broad-spectrum antimicrobial activity. Lead compound P1 could disrupt bacterial membranes rapidly without developing resistance, inhibit biofilms formed by E. coli, and exhibit excellent in vivo activity in an MRSA-infected thigh burden mouse model.

SUBMITTER: Su M 

PROVIDER: S-EPMC10484568 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature