Exploring the relationship between lactate metabolism and immunological function in colorectal cancer through genes identification and analysis.

ABSTRACT: Introduction: Metabolic dysregulation is a widely acknowledged contributor for the development and tumorigenesis of colorectal cancer (CRC), highlighting the need for reliable prognostic biomarkers in this malignancy. Methods: Herein, we identified key genes relevant to CRC metabolism through a comprehensive analysis of lactate metabolism-related genes from GSEA MsigDB, employing univariate Cox regression analysis and random forest algorithms. Clinical prognostic analysis was performed following identification of three key genes, and consistent clustering enabled the classification of public datasets into three patterns with significant prognostic differences. The molecular pathways and tumor microenvironment (TME) of these patterns were then investigated through correlation

SUBMITTER: Zhang E 

PROVIDER: S-EPMC10484590 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature