Direct m6A recognition by IMP1 underlays an alternative model of target selection for non-canonical methyl-readers.

ABSTRACT: m6A methylation provides an essential layer of regulation in organismal development, and is aberrant in a range of cancers and neuro-pathologies. The information encoded by m6A methylation is integrated into existing RNA regulatory networks by RNA binding proteins that recognise methylated sites, the m6A readers. m6A readers include a well-characterised class of dedicated proteins, the YTH proteins, as well as a broader group of multi-functional regulators where recognition of m6A is only partially understood. Molecular insight in this recognition is essential to build a mechanistic understanding of global m6A regulation. In this study, we show that the reader IMP1 recognises the m6A using a dedicated hydrophobic platform that assembles on the methyl moiety, creating a stable high-affinity

SUBMITTER: Nicastro G 

PROVIDER: S-EPMC10484666 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature