White matter microstructural alterations in patients with neuropathic pain after spinal cord injury: a diffusion tensor imaging study.

ABSTRACT:

Background

Through contrastive analysis, we aimed to identify the white matter brain regions that show microstructural changes in patients with neuropathic pain (NP) after spinal cord injury (SCI).

Methods

We categorized patients with SCI into NP (n = 30) and non-NP (n = 15) groups. We extracted diffusion tensor maps of fractional anisotropy (FA) and mean (MD), axial (AD), and radial (RD) diffusivity. A randomization-based method in tract-based spatial statistics was used to perform voxel-wise group comparisons among the FA, MD, AD, and RD for nonparametric permutation tests.

Results

Atlas-based analysis located significantly different regions (p < 0.05) in the appointed brain atlas. Compared to the non-NP group, the NP group showed higher FA in t

SUBMITTER: Dong D 

PROVIDER: S-EPMC10484711 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature