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Comparative pathogenicity of Scedosporium species in murine model of systemic scedosporiosis.

ABSTRACT: Systemic scedosporiosis is a devastating emerging fungal infection caused by several species of the genus Scedosporium in immunocompetent and immunocompromised individuals. In this study, we compared the virulence of different Scedosporium species in a murine model of systemic scedosporiosis by survival assays, fungal burden and histopathological analysis. We found that mice mortality was species-dependent, S. apiospermum, S. aurantiacum and S. dehoogii were the most virulent species. We also observed the dissemination and invasion of Scedosporium species to the brain, spleen and kidney by colony count and histopathological analysis at different times of infection. Particularly, the brain was the tissue most susceptible to invasion during systemic scedosporiosis. This study shows the virulence and pathophysiology of different Scedosporium species and will be useful in facilitating control and prevention strategies for systemic scedosporiosis.

SUBMITTER: Elizondo-Zertuche M

PROVIDER: S-EPMC10484889 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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Comparative pathogenicity of Scedosporium species in murine model of systemic scedosporiosis.

Elizondo-Zertuche Mariana M Flores-Maldonado Orlando O González Gloria M GM Becerril-Garcia Miguel M

Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] 20230715 3

Systemic scedosporiosis is a devastating emerging fungal infection caused by several species of the genus Scedosporium in immunocompetent and immunocompromised individuals. In this study, we compared the virulence of different Scedosporium species in a murine model of systemic scedosporiosis by survival assays, fungal burden and histopathological analysis. We found that mice mortality was species-dependent, S. apiospermum, S. aurantiacum and S. dehoogii were the most virulent species. We also ob ...[more]

PMID: 37453029

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Dataset Information

Comparative pathogenicity of Scedosporium species in murine model of systemic scedosporiosis.

Publications

Comparative pathogenicity of Scedosporium species in murine model of systemic scedosporiosis.

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