In vivo deuterium magnetic resonance imaging of xenografted tumors following systemic administration of deuterated water.

ABSTRACT: In vivo deuterated water (²H₂O) labeling leads to deuterium (²H) incorporation into biomolecules of proliferating cells and provides the basis for its use in cell kinetics research. We hypothesized that rapidly proliferating cancer cells would become preferentially labeled with ²H and, therefore, could be visualized by deuterium magnetic resonance imaging (dMRI) following a brief period of in vivo systemic ²H₂O administration. We initiated systemic ²H₂O administration in two xenograft mouse models harboring either human colorectal, HT-29, or pancreatic, MiaPaCa-2, tumors and ²H₂O level of ~ 8% in total body water (TBW). Three schemas of ²H₂O administration wer

SUBMITTER: Brender JR 

PROVIDER: S-EPMC10485001 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature