All-round catalytic and atroposelective strategy via dynamic kinetic resolution for N-/2-/3-arylindoles.

ABSTRACT: As the complexity of organic molecules utilized by mankind increases, the phenomenon of atropisomerism is more frequently encountered. While a variety of well-established methods enable the control of a stereogenic center, a catalytic method for controlling a stereogenic axis in one substrate is typically unavailable for controlling axial chirality in other substrates with a similar structure. Herein, we report o-amidobiaryl as a flexible platform for chiral phosphoric acid-catalyzed atroposelective dynamic kinetic resolution. To demonstrate our strategy, three distinct types of arylindoles were utilized and reacted intermolecularly with ketomalonate in the presence of chiral phosphoric acid. An investigation of 46 substrates having an aromatic ring in different positions yields the desire

SUBMITTER: Kim A 

PROVIDER: S-EPMC10485016 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature