Ontology highlight
ABSTRACT:
SUBMITTER: Mihaylov SR
PROVIDER: S-EPMC10485026 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Nature communications 20230907 1
PGC-1α plays a central role in maintaining mitochondrial and energy metabolism homeostasis, linking external stimuli to transcriptional co-activation of genes involved in adaptive and age-related pathways. The carboxyl-terminus encodes a serine/arginine-rich (RS) region and an RNA recognition motif, however the RNA-processing function(s) were poorly investigated over the past 20 years. Here, we show that the RS domain of human PGC-1α directly interacts with RNA and the nuclear RNA export recepto ...[more]