Modulation of colonic immunometabolic responses during Clostridioides difficile infection ameliorates disease severity and inflammation.

ABSTRACT: Clostridioides difficile infection (CDI) is the leading cause of antibiotic-associated diarrhea, and its clinical symptoms can span from asymptomatic colonization to pseudomembranous colitis and even death. The current standard of care for CDI is antibiotic treatment to achieve bacterial clearance; however, 15 to 35% of patients experience recurrence after initial response to antibiotics. We have conducted a comprehensive, global colonic transcriptomics analysis of a 10-day study in mice to provide new insights on the local host response during CDI and identify novel host metabolic mechanisms with therapeutic potential. The analysis indicates major alterations of colonic gene expression kinetics at the acute infection stage, that are restored during the recovery phase. At the metabolic lev

SUBMITTER: Tubau-Juni N 

PROVIDER: S-EPMC10485029 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature