Distinct N7-methylguanosine profiles of circular RNAs in drug-resistant acute myeloid leukemia.

ABSTRACT: Post-transcriptional methylation modifications, such as the N7-methylguanosine (m7G) modification, are increasingly acknowledged for their role in the development and resistance to chemotherapy in acute myeloid leukemia (AML). This study employed MeRIP-seq technology to investigate the m7G sites within circular RNAs (circRNAs) derived from human AML cells and drug-resistant AML cells, in order to identify these sites more comprehensively. In addition, a detailed analysis of the relationship between m7G and drug-resistant AML was conducted. The bioinformatics analysis was utilized to predict the functions of specific methylated transcripts. The findings revealed a significant difference in m7G level between AML cells and drug-resistant AML cells, suggesting a potentially critical role of m7

SUBMITTER: Fu J 

PROVIDER: S-EPMC10485064 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature