Temporal and spatial dynamics of immune cells in spontaneous liver transplant tolerance.

ABSTRACT: The liver has long been deemed a tolerogenic organ. We employed high-dimensional mass cytometry and immunohistochemistry to depict the temporal and spatial dynamics of immune cells in the spleen and liver in a murine model of spontaneous liver allograft acceptance. We depicted the immune landscape of spontaneous liver tolerance throughout the rejection and acceptance stages after liver transplantation and highlighted several points of importance. Of note, the CD4⁺/CD8⁺ T cell ratio remained low, even in the tolerance phase. Furthermore, a PhenoGraph clustering analysis revealed that exhausted CD8⁺ T cells were the most dominant metacluster in graft-infiltrating lymphocytes (GILs), which highly expressed the costimulatory molecule CD86. The temporal and spat

SUBMITTER: Que W 

PROVIDER: S-EPMC10485166 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature