Resting-state functional connectivity is modulated by cognitive reserve in early Parkinson's disease.

ABSTRACT:

Background

Fronto-striatal disconnection is thought to be at the basis of dysexecutive symptoms in patients with Parkinson's disease (PD). Multiple reserve-related processes may offer resilience against functional decline. Among these, cognitive reserve (CR) refers to the adaptability of cognitive processes.

Objective

To test the hypothesis that functional connectivity of pathways associated with executive dysfunction in PD is modulated by CR.

Methods

Twenty-six PD patients and 24 controls underwent resting-state functional magnetic resonance imaging. Functional connectivity was explored with independent component analysis and seed-based approaches. The following networks were selected from the outcome of the independent component analysis: default-mode (DMN), left an

SUBMITTER: Di Tella S 

PROVIDER: S-EPMC10485267 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature