The Mutational, Prognostic, and Therapeutic Landscape of Neuroendocrine Neoplasms.

ABSTRACT:

Background

Neuroendocrine neoplasms (NENs) represent clinically and genetically heterogeneous malignancies, thus a comprehensive understanding of underlying molecular characteristics, prognostic signatures, and potential therapeutic targets is urgently needed.

Methods

Next-generation sequencing (NGS) and immunohistochemistry were applied to acquire genomic and immune profiles of NENs from 47 patients.

Results

Difference was distinguished based on differentiation grade and primary localization. Poorly differentiated neuroendocrine carcinomas (NECs) and well-differentiated neuroendocrine tumors (NETs) harbored distinct molecular features; we observed that tumor mutational burden (TMB) and tumor neoantigen burden (TNB) were significantly higher in NECs versus NETs. Notab

SUBMITTER: Liu M 

PROVIDER: S-EPMC10485279 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature