Prolonged Survival of NUT Midline Carcinoma and Current Approaches to Treatment.

ABSTRACT: NUT midline carcinoma is a rare malignancy most commonly seen in adolescents and young adults. The disease presents most often in the lung or head and neck area but can be seen occasionally elsewhere. The diagnosis can be difficult and requires a high degree of suspicion with demonstration of the classic fusion rearrangement mutation of the NUTM1 gene with one of a variety of partners by immunohistochemistry, fluorescent in situ hybridization, or genomic analysis. Survival is usually only a number of months with few long-term survivors. Here we report one of the longest-known survivors of this disease treated with surgery and radiation without additional therapy. Systemic treatment approaches including the use of chemotherapy and BET and histone deacetylase inhibitors have yielded modest r

SUBMITTER: Kaplan HG 

PROVIDER: S-EPMC10485280 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature