The m⁶A-related gene signature stratifies poor prognosis patients and characterizes immunosuppressive microenvironment in hepatocellular carcinoma.

ABSTRACT:

Background

N⁶-methyladenosine (m⁶A) is the most abundant epitranscriptomic modification of RNA, which can affect RNA metabolism and protein translation. The m⁶A modification plays a critical role in cancer development, including hepatocellular carcinoma (HCC). Despite several m⁶A-related signatures in HCC, most of them lack the necessary validation and the reliability is still elusive.

Methods

Differentially expressed genes (DEGs) in the Cancer Genome Atlas were comprehensively analyzed to identify m⁶A signature associated with HCC prognosis. Gene set enrichment analysis, tumor mutation burden (TMB), immune infiltration, and therapeutic response were evaluated. Importantly, mass spectrometry proteomics and multiplex immu

SUBMITTER: Ma E 

PROVIDER: S-EPMC10485364 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature