Parkinson's disease model in zebrafish using intraperitoneal MPTP injection.

ABSTRACT:

Introduction

Parkinson's disease (PD) is the second most common neurodegenerative disease that severely affects the quality of life of patients and their family members. Exposure to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) has been shown to reflect behavioral, molecular, and proteomic features of PD. This study aimed to assess the protocol for inducing PD following MPTP injection in adult zebrafish.

Methods

Fish were injected with 100 μg/g of MPTP intraperitoneally once or twice and then assessed on days 1 to 30 post-injection.

Results

Between one-time and two-time injections, there was no significant difference in most locomotor parameters, expressions of tyrosine hydroxylase-2 (th2) and dopamine transporter (dat) genes, and dop

SUBMITTER: Omar NA 

PROVIDER: S-EPMC10485380 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature