Redirector of Vaccine-induced Effector Responses (RoVER) for specific killing of cellular targets.

ABSTRACT:

Background

In individuals with malignancy or HIV-1 infection, antigen-specific cytotoxic T lymphocytes (CTLs) often display an exhausted phenotype with impaired capacity to eliminate the disease. Existing cell-based immunotherapy strategies are often limited by the requirement for adoptive transfer of CTLs. We have developed an immunotherapy technology in which potent CTL responses are generated in vivo by vaccination and redirected to eliminate target cells using a bispecific Redirector of Vaccine-induced Effector Responses (RoVER).

Methods

Following Yellow fever (YF) 17D vaccination of 51 healthy volunteers (NCT04083430), single-epitope YF-specific CTL responses were quantified by tetramer staining and multi-parameter flow cytometry. RoVER-mediated redirection of YF-specif

SUBMITTER: Konrad CV 

PROVIDER: S-EPMC10485592 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature