Caffeine intake interacts with Asian gene variants in Parkinson's disease: a study in 4488 subjects.

ABSTRACT:

Background

Caffeine intake reduces risk of Parkinson's disease (PD), but the interaction with genes is unclear. The interaction of caffeine with genetic variants in those at high PD risk has healthcare importance. We investigate interactions of caffeine intake with risk variants found in Asians, and determine PD risk estimates in caffeine-drinkers carrying these variants.

Methods

PD patients and controls without neurological disorders were included. Caffeine intake was assessed using a validated evaluation tool. Leucine rich repeat kinase 2 (LRRK2) risk variants were genotyped. Statistical analysis was conducted with logistic regression models. Gene-caffeine interactions were quantified using attributable proportion (AP) due to interaction (positive interaction defined as AP

SUBMITTER: Ong YL 

PROVIDER: S-EPMC10485627 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature