Comprehensive analysis of P2Y family genes expression, immune characteristics, and prognosis in pan-cancer.

ABSTRACT:

Background

P2Y receptors are a family of G protein-coupled receptor genes that have an important function in cancer development and metastasis. However, systematic studies have not been conducted on human tumors. This study attempted to explore the role of P2Y family genes (P2Ys) in pan-cancer.

Methods

Gene expression and clinical data were downloaded from The Cancer Genome Alas dataset. Gene differential expression, mutation, prognosis, tumor microenvironment (TME) (containing immune cells infiltration, Estimate/immune/stromal scores, immune checkpoints, immune and molecular subtypes, DNA repair genes and methyltransferase), clinical correlation, protein-protein interaction network and functional enrichment analysis were performed. In addition, experiments such as western b

SUBMITTER: Liu C 

PROVIDER: S-EPMC10485639 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature