Cardiac tissue engineering for the treatment of hypoplastic left heart syndrome (HLHS).

ABSTRACT: Hypoplastic left heart syndrome (HLHS) is a deadly congenital heart disease that arises when the left ventricle and outflow tract fail to develop appropriately, inhibiting the adequate perfusion of the rest of the body. Historically, this disease has been treated via a series of surgeries that allows the heart to use a single ventricle. These surgeries are often a palliative measure, and heart transplantation is the only definitive therapy that exists for this condition. It has been hypothesized that stem cell-based regenerative therapies could have a role in promoting cardiac tissue regeneration in HLHS patients who are undergoing palliative surgery. Several clinical trials have demonstrated that introducing pluripotent cells into the heart is safe, feasible, and capable of improving righ

SUBMITTER: Abraham R 

PROVIDER: S-EPMC10485645 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature