A narrative review on treatment strategies for neonatal hypoxic ischemic encephalopathy.

ABSTRACT:

Background and objective

Hypoxic-ischemic encephalopathy (HIE) is a leading cause of death and disability worldwide. Therapeutic hypothermia (TH) represents a significant achievement in the translation of scientific research to clinical application, but it is currently the only neuroprotective treatment for HIE. This review aims to revisit the use of TH for HIE and its longitudinal impact on patient outcomes to readers new to the field of HIE. We discuss how emerging therapies address the broader pathophysiology of injury progression in the neonatal brain days to years after HIE.

Methods

We included full articles and book chapters published in English on PubMed with references to "hypoxic ischemic encephalopathy", "birth asphyxia", "therapeutic hypothermia", or "neonatal enc

SUBMITTER: Korf JM 

PROVIDER: S-EPMC10485647 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature