Cannabis sativa: origin and history, glandular trichome development, and cannabinoid biosynthesis.

ABSTRACT: Is Cannabis a boon or bane? Cannabis sativa has long been a versatile crop for fiber extraction (industrial hemp), traditional Chinese medicine (hemp seeds), and recreational drugs (marijuana). Cannabis faced global prohibition in the twentieth century because of the psychoactive properties of ∆⁹-tetrahydrocannabinol; however, recently, the perspective has changed with the recognition of additional therapeutic values, particularly the pharmacological potential of cannabidiol. A comprehensive understanding of the underlying mechanism of cannabinoid biosynthesis is necessary to cultivate and promote globally the medicinal application of Cannabis resources. Here, we comprehensively review the historical usage of Cannabis, biosynthesis of trichome-

SUBMITTER: Xie Z 

PROVIDER: S-EPMC10485653 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature