Endemicity and diversification of carbapenem-resistant <i>Acinetobacter baumannii</i> in an intensive care unit.

ABSTRACT:

Background

Carbapenem-resistant Acinetobacter baumannii (CRAB) is a major public health concern globally. Often studied in the context of hospital outbreaks, little is known about the persistence and evolutionary dynamics of endemic CRAB populations.

Methods

A three-month cross-sectional observational study was conducted in a 28-bed intensive care unit (ICU) in Hangzhou, China. A total of 5068 samples were collected from the hospital environment (n = 3985), patients (n = 964) and staff (n = 119). CRAB isolates were obtained from 10.5% of these samples (n = 532). All of these isolates, plus an additional 19 from clinical infections, were characterised through whole-genome sequencing.

Findings

The ICU CRAB population was dominated by OXA-23-producing global clone

SUBMITTER: Doughty EL 

PROVIDER: S-EPMC10485671 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature