Analytical approaches for antimalarial antibody responses to confirm historical and recent malaria transmission: an example from the Philippines.

ABSTRACT:

Background

Assessing the status of malaria transmission in endemic areas becomes increasingly challenging as countries approach elimination. Serology can provide robust estimates of malaria transmission intensities, and multiplex serological assays allow for simultaneous assessment of markers of recent and historical malaria exposure.

Methods

Here, we evaluated different statistical and machine learning methods for analyzing multiplex malaria-specific antibody response data to classify recent and historical exposure to Plasmodium falciparum and Plasmodium vivax. To assess these methods, we utilized samples from a health-facility based survey (n = 9132) in the Philippines, where we quantified antibody responses against 8 P. falciparum and 6 P. vivax

SUBMITTER: Macalinao MLM 

PROVIDER: S-EPMC10485684 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature